Members of the mammalian PAX (paired box) family of genes were initially
identified due to sequence homology to the Drosophila segmentation genes
paired and gooseberry (Burri
M., 1989).
PAX1, expressed in the developing vertebral column, is associated with
the undulated phenotype in the mouse. PAX
family by Amy Voltz
Expression Patterns:
The mouse paired-box-containing genes Pax-2, Pax-5
and Pax-8 show overlapping expression with the En genes in the developing
brain. (Song D. L., 1996)
En-1,
En-2, Pax-2 and Wnt-7a
in developing murine cerebellum.
Mutations of Pax genes causes abnormal development of eye, ear or kidney
(See The PathoDB database).
Bibliography:
Plaza, 1994
Pax-QNR/Pax-6, a paired- and homeobox-containing protein, recognizes Ets
binding sites and can alter the transactivating properties of Ets transcription
factors.
Gene Expr 4, 43-52 (1994) [95143936]
(View Citation
format )
Plaza, 1995
C-Myb acts as transcriptional activator of the quail PAX6 (PAX-QNR) promoter
through two different mechanisms.
Oncogene 10, 329-340 (1995) [95140422]
(View Citation
format )
Plaza, 1995
Identification and characterization of a neuroretina-specific enhancer
element in the quail Pax-6 (Pax-QNR) gene.
Mol Cell Biol 15, 892-903 (1995) [95124347]
Two
Pax-binding sites are required for early embryonic brain expression of
an Engrailed-2 transgene. Development 122: 627-635 (1996)
Pax-2
expression in the murine neural plate precedes and encompasses the expression
domains of Wnt-1 and En-1. Mech Dev 52: 3-8 (1995)
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En-1,
En-2, Pax-2 and Wnt-7a
in developing murine cerebellum.