Homeobox Genes DataBase

Vertebrate/Drosophila Genes In Development:

Vertebrate Antp-like HOX gene

Mix.2

Definition:

Xenopus laevis homeobox gene Mix.2 is responsive to mesoderm induction signals. The mesoderm of Xenopus arises through an inductive interaction in which signals from the vegetal hemisphere of the embryo act on overlying equatorial cells. One candidate for an endogenous mesoderm-inducing factor is activin, a member of the TGFbeta superfamily. Activin induces different mesodermal cell types in a concentration-dependent manner, suggesting that it acts as a morphogen.

Promoter Regions:

Regulatory Connections:

Downstream Genes:

• Interaction Type: -
• Interaction Status: -
• Experimental Proofs: -
• References: -

Upstream Genes:

• Activin
• Interaction Type: activation
• Interaction Status: possibly direct
• Experimental Proofs: microinjected Mix.2 gene plasmids respond to activin in the presence of cycloheximide in animal cap assays
• References:

Vize PD. DNA sequences mediating the transcriptional response of the Mix.2 homeobox gene to mesoderm induction. Dev Biol 1996 Jul 10;177(1):226-231

Gene Sequences:

1. Xenopus laevis homeobox protein Mix.2 mRNA, complete cds gi|1256256|gb|U50745|XLU50745 [1256256]

Bibliography:

Vize PD. DNA sequences mediating the transcriptional response of the Mix.2 homeobox gene to mesoderm induction. Dev Biol 1996 Jul 10;177(1):226-231