Drosophila/Vertebrate Genes in Development:
Gap gene family
Gap gene Kruppel (Kr) encodes a zinc finger protein with four tandomly repeated zinc finger domains.
Zinc finger protein with four tandomly repeated zinc finger domains.
Two cis-acting control elements, CD1 and CD2, control early expression. CD2 is located at -1000 to -3000 from start of transcription, and CD1 is at -3000 to -4000.
| Regulatory element | Localisation of element | Trans-regulatory factor | Reference | ||
| CD1 (Kr750 element) | 5'-flanking region | HUNCHBACK
(+),
BICOID (+), GIANT (-), TAILLESS (-), KNIRPS (-) |
Hoch
et al., 1992,
Hoch et al., 1991 |
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Upstream Genes |
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fd |
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posterior sex combs |
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krueppel |
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| cad | hb | kni | gt | en | eve | h | run | prd | AbdA | AbdB | antp | zen | cut | gsb-n |
Downstream Genes |
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HOM-C
HOX-Pro
Comments are welcome to Alex Spirov