Homeobox Genes DataBase

Drosophila/Vertebrate Genes in Development:

Pair-rule family

even-skipped

Definition:

Function

even-skipped (eve) is a pair-rule gene that encodes a homeobox transcription factor. Even-skipped is a transcriptional repressor of a number of genes.

eve is expressed in a pattern of seven evenly spaced stripes in the precellular embryo. It play a key role in the establishment of the metameric body plan.

Protein:

homeodomain protein, DNA-binding transcription factor.

Patterns of Expression:

3D representation of EVE pattern

Regulatory Regions:

Idiomyia grimshawi sequence at -10 kb relative to even-skipped transcriptional start site (Sequence conserved between D. melanogaster and I. Grimshawi.)

Regulatory element	Localisation of element	Trans-regulatory factor	Reference
stripe#2 enhancer stripe#2 enhancer[Dm:Or-rc] stripe#2 enhancer[Dm:Wa-f] stripe#2 enhancer[Dm:Zn56] stripe#2 enhancer[Dm:Af-s] stripe#2 enhancer[Dm:Fl-s] stripe#2 enhancer[Ds:cn bw] stripe#2 enhancer[Ds:Im14] stripe#2 enhancer[Ds:LA] stripe#2 enhancer[Ds:MA] stripe#2 enhancer[Ds:Im7] stripe#2 enhancer[Ds:HA]	5'flanking region	BICOID (+), HUNCHBACK(+), GIANT (-), KRUEPPEL (-)	Ludwig & Kreitman, 1995 . . . . . . . . . Small et al., 1992
stripe#3 + #7 enhancer	-"-	JAK-Stat cascade(+), HUNCHBACK(-), KRUEPPEL (-)	Small et al., 1996
autoregulatory element	-"-	EVEN-SKIPPED	Jiang et al., 1991