decapentaplegic is responsible for dorsal/ventral polarity in the
fly. In a second phase of its activity, as segments appear, dpp
functions in the definition of boundaries between segmental compartments.
As part of this process, dpp, along with wingless and hedgehog,
defines the position of future limbs, including wings, legs and antenna.
dpp also has an independent role in the structuring of the mesoderm.
Later, during the final process of appendage development, and acting downstream
of engrailed and hedgehog, dpp defines boundaries
between appendage compartments assuring correct anterior/posterior polarity.
dpp has an analogous function in the development of the eye, where
it is primarily responsible for the progression of the morphogenetic furrow,
the induction site of the Drosophila retina.
HOM-C
HOX-Pro